Tips for booking flights:

In general you have 3 possibilities to travel from Europe to Mosselbay, South Africa:

1. Direct flights to Cape Town and travel on by car (4 hours)
2. Direct flights to Johannesburg with a conncetion flight to George 
   and travel on by car (only 30- minute drive from George Airport to Dana Bay)
3. Direct flights to Johannesburg and travel on by car to Mosselbay (2 days)

Our favorite carrier:
KLM via Amsterdam to Cape Town or Johannesburg (day flights)
rather good service, board language & movies in different languages, pleasant stop over at Schiphol Airport

More flight connections:

• Air Namibia from Frankfurt/Main via Windhoek to Cape Town (Stopover in Windhoek and visit the Etosha-National-Park)
• Air France via Paris to Johannesburg
• British Airways via London to Cape Town or Johannesburg
• Emirates via Dubai to Johannesburg (we can recommend a 2 nights stopover sightseeing in Dubai)
• Qatar Airways via Doha to Johannesburg / Cape Town (recommendation: 2 nights stopover in Doha with a desert safari)
• Iberia via Madrid to Johannesburg
• LTU from Frankfurt/Main to Cape Town
• Lufthansa from Frankfurt/Main to Cape Town or Johannesburg
• South African Airways from London, Paris, Zürich, Frankfurt/M. to Cape Town or Johannesburg

You can book inland flights, for example Johannesburg (JNB) to George (GRJ), under http://www.southafrica.to/transport/Airlines/South-Africa-within/flights-to-george/cheap-flights-Johannesburg-to-George.php5. There are also other airlines serving this connection.

Tips for car hire:

All international car hire companies are available:

Budget         http://www.budget.co.za
Sixt              http://www.sixt.co.za
Avis             http://www.avis.co.za/main.asp?ID=243&RootItemID=243
Europcar      http://www.europcar.co.za  

Check them out! Prices differ, some times you have special offers.